(195) Pt NMR parameters as strong descriptors in one-parameter QSAR models for platinum-based antitumor compounds.

Title (195) Pt NMR parameters as strong descriptors in one-parameter QSAR models for platinum-based antitumor compounds.
Authors A.C. Tsipis; I.N. Karapetsas
Journal Magn Reson Chem
DOI 10.1002/mrc.4570
Abstract

Highly predictive one-parameter quantitative structure-activity relationship models have been developed for platinum-based anticancer drugs using the (195) Pt NMR parameters as strong descriptors. The developed quantitative structure-activity relationship models were applied in diverse homogeneous sets of antiproliferative Pt(II) and Pt(IV) compounds. These observations form the basis for making predictions of cytotoxicity for a broad range of platinum-based antitumor compounds just from inspection of calculated or experimentally determined (195) Pt NMR parameters. Copyright © 2016 John Wiley & Sons, Ltd.

Citation A.C. Tsipis; I.N. Karapetsas.(195) Pt NMR parameters as strong descriptors in one-parameter QSAR models for platinum-based antitumor compounds.. Magn Reson Chem. 2017;55(7):662669. doi:10.1002/mrc.4570

Related Elements

Platinum

See more Platinum products. Platinum (atomic symbol: Pt, atomic number: 78) is a Block D, Group 10, Period 6 element with an atomic weight of 195.084. The number of electrons in each of platinum's shells is [2, 8, 18, 32, 17, 1] and its electron configuration is [Xe] 4f14 5d9 6s1. The platinum atom has a radius of 139 pm and a Van der Waals radius of 175 pm. Platinum Bohr ModelElemental PlatinumPlatinum was discovered and first isolated by Antonio de Ulloa in 1735. It is one of the rarest elements in the earth's crust, occurring at a concentration of only 0.005 ppm. Platinum is found uncombined as a free element and alloyed with iridium as platiniridium. In its elemental form, platinum has a grayish white appearance. It is highly resistant to corrosion: the metal does not oxidize in air at any temperature. It is generally non-reactive, even at high temperatures. The origin of the name "platinum" comes from the Spanish word platina, meaning silver.