3D skeletal uptake of (18)F sodium fluoride in PET/CT images is associated with overall survival in patients with prostate cancer.

Title 3D skeletal uptake of (18)F sodium fluoride in PET/CT images is associated with overall survival in patients with prostate cancer.
Authors S.Lindgren Belal; M. Sadik; R. Kaboteh; N. Hasani; O. Enqvist; L. Svärm; F. Kahl; J. Simonsen; M.H. Poulsen; M. Ohlsson; P.F. Høilund-Carlsen; L. Edenbrandt; E. Trägårdh
Journal EJNMMI Res
DOI 10.1186/s13550-017-0264-5
Abstract

BACKGROUND: Sodium fluoride (NaF) positron emission tomography combined with computer tomography (PET/CT) has shown to be more sensitive than the whole-body bone scan in the detection of skeletal uptake due to metastases in prostate cancer. We aimed to calculate a 3D index for NaF PET/CT and investigate its correlation to the bone scan index (BSI) and overall survival (OS) in a group of patients with prostate cancer.

METHODS: NaF PET/CT and bone scans were studied in 48 patients with prostate cancer. Automated segmentation of the thoracic and lumbar spines, sacrum, pelvis, ribs, scapulae, clavicles, and sternum were made in the CT images. Hotspots in the PET images were selected using both a manual and an automated method. The volume of each hotspot localized in the skeleton in the corresponding CT image was calculated. Two PET/CT indices, based on manual (manual PET index) and automatic segmenting using a threshold of SUV 15 (automated PET15 index), were calculated by dividing the sum of all hotspot volumes with the volume of all segmented bones. BSI values were obtained using a software for automated calculations.

RESULTS: BSI, manual PET index, and automated PET15 index were all significantly associated with OS and concordance indices were 0.68, 0.69, and 0.70, respectively. The median BSI was 0.39 and patients with a BSI >0.39 had a significantly shorter median survival time than patients with a BSI <0.39 (2.3 years vs not reached after 5 years of follow-up [p?=?0.01]). The median manual PET index was 0.53 and patients with a manual PET index >0.53 had a significantly shorter median survival time than patients with a manual PET index <0.53 (2.5 years vs not reached after 5 years of follow-up [p?0.11 had a significantly shorter median survival time than patients with an automated PET15 index <0.11 (2.3 years vs not reached after 5 years of follow-up [p?

CONCLUSIONS: PET/CT indices based on NaF PET/CT are correlated to BSI and significantly associated with overall survival in patients with prostate cancer.

Citation S.Lindgren Belal; M. Sadik; R. Kaboteh; N. Hasani; O. Enqvist; L. Svärm; F. Kahl; J. Simonsen; M.H. Poulsen; M. Ohlsson; P.F. Høilund-Carlsen; L. Edenbrandt; E. Trägårdh.3D skeletal uptake of (18)F sodium fluoride in PET/CT images is associated with overall survival in patients with prostate cancer.. EJNMMI Res. 2017;7(1):15. doi:10.1186/s13550-017-0264-5

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Fluorine is a Block P, Group 17, Period 2 element. Its electron configuration is [He]2s22p5. The fluorine atom has a covalent radius of 64 pm and its Van der Waals radius is 135 pm. In its elemental form, CAS 7782-41-4, fluorine gas has a pale yellow appearance. Fluorine was discovered by André-Marie Ampère in 1810. It was first isolated by Henri Moissan in 1886.

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