A non-chiral lithium aluminate reagent for the determination of enantiomeric excess of chiral alcohols.

Title A non-chiral lithium aluminate reagent for the determination of enantiomeric excess of chiral alcohols.
Authors R. García-Rodríguez; S. Hanf; A.D. Bond; D.S. Wright
Journal Chem Commun (Camb)
DOI 10.1039/c6cc09671a
Abstract

Here we illustrate a new method for the rapid determination of ee's of chiral alcohols using the thermally-stable, non-chiral lithium aluminate reagent [EtAl(6-Me-2-py)3Li] (1). In situ reaction of the alcohols with 1 produces robust dimers in solution, present as diastereomeric pairs (SS/RR and RS) with distinct resonances in their (1)H and (7)Li NMR spectra. The ee can be calculated simply from integration of the (1)H and/or (7)Li NMR spectra.

Citation R. García-Rodríguez; S. Hanf; A.D. Bond; D.S. Wright.A non-chiral lithium aluminate reagent for the determination of enantiomeric excess of chiral alcohols.. Chem Commun (Camb). 2017;53(7):12251228. doi:10.1039/c6cc09671a

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