Adsorption of Oligo-DNA on Magnesium Aluminum-Layered Double-Hydroxide Nanoparticle Surfaces: Mechanistic Implication in Gene Delivery.

Title Adsorption of Oligo-DNA on Magnesium Aluminum-Layered Double-Hydroxide Nanoparticle Surfaces: Mechanistic Implication in Gene Delivery.
Authors K.A. Andrea; L. Wang; A.J. Carrier; M. Campbell; M. Buhariwalla; M.K. Mutch; S.L. MacQuarrie; C. Bennett; M. Mkandawire; K. Oakes; M. Lu; X. Zhang
Journal Langmuir
DOI 10.1021/acs.langmuir.6b04172
Abstract

Magnesium aluminum-layered double-hydroxide nanoparticles (LDH NPs) are promising drug-delivery vehicles for gene therapy, particularly for siRNA interference; however, the interactions between oligo-DNA and LDH surfaces have not been adequately elucidated. Through a mechanistic study, oligo-DNA initially appears to rapidly bind strongly to the LDH outer surfaces through interactions with their phosphate backbones via ligand exchange with OH(-) on Mg(2+) centers and electrostatic forces with Al(3+). These initial interactions might precede diffusion into interlayer spaces, and this knowledge can be used to design better gene therapy delivery systems.

Citation K.A. Andrea; L. Wang; A.J. Carrier; M. Campbell; M. Buhariwalla; M.K. Mutch; S.L. MacQuarrie; C. Bennett; M. Mkandawire; K. Oakes; M. Lu; X. Zhang.Adsorption of Oligo-DNA on Magnesium Aluminum-Layered Double-Hydroxide Nanoparticle Surfaces: Mechanistic Implication in Gene Delivery.. Langmuir. 2017. doi:10.1021/acs.langmuir.6b04172

Related Elements

Aluminum

See more Aluminum products. Aluminum (or Aluminium) (atomic symbol: Al, atomic number: 13) is a Block P, Group 13, Period 3 element with an atomic weight of 26.9815386. It is the third most abundant element in the earth's crust and the most abundant metallic element. Aluminum Bohr Model Aluminum's name is derived from alumina, the mineral from which Sir Humphrey Davy attempted to refine it from in 1812. Aluminum was first predicted by Antoine Lavoisier 1787 and first isolated by Hans Christian Øersted in 1825. Aluminum is a silvery gray metal that possesses many desirable characteristics. It is light, nonmagnetic and non-sparking. It stands second among metals in the scale of malleability, and sixth in ductility. It is extensively used in many industrial applications where a strong, light, easily constructed material is needed. Elemental AluminumAlthough it has only 60% of the electrical conductivity of copper, it is used in electrical transmission lines because of its light weight. Pure aluminum is soft and lacks strength, but alloyed with small amounts of copper, magnesium, silicon, manganese, or other elements, it imparts a variety of useful properties.

Magnesium

Magnesium Bohr ModelSee more Magnesium products. Magnesium (atomic symbol: Mg, atomic number: 12) is a Block S, Group 2, Period 3 element with an atomic mass of 24.3050. The number of electrons in each of Magnesium's shells is [2, 8, 2] and its electron configuration is [Ne] 3s2. The magnesium atom has a radius of 160 pm and a Van der Waals radius of 173 pm. Magnesium was discovered by Joseph Black in 1775 and first isolated by Sir Humphrey Davy in 1808. Magnesium is the eighth most abundant element in the earth's crust and the fourth most common element in the earth as a whole. Elemental MagnesiumIn its elemental form, magnesium has a shiny grey metallic appearance and is an extremely reactive. It is can be found in minerals such as brucite, carnallite, dolomite, magnesite, olivine and talc. Commercially, magnesium is primarily used in the creation of strong and lightweight aluminum-magnesium alloys, which have numerous advantages in industrial applications. The name "Magnesium" originates from a Greek district in Thessaly called Magnesia.

Related Forms & Applications