Anti-staphylococcal biofilm activity of miconazoctylium bromide.

Title	Anti-staphylococcal biofilm activity of miconazoctylium bromide.
Authors	J. Tessier; M. Golmohamadi; K.J. Wilkinson; A.R. Schmitzer
Journal	Org Biomol Chem
DOI	10.1039/c8ob00897c
Abstract	We designed and synthesized miconazole analogues containing a substituted imidazolium moiety. The structural modification of the miconazole led to a compound with high potency to prevent the formation and disrupt bacterial biofilms, as a result of accumulation in the biofilm matrix, permeabilization of the bacterial membrane and generation of reactive oxygen species in the cytoplasm.
Citation	J. Tessier; M. Golmohamadi; K.J. Wilkinson; A.R. Schmitzer.Anti-staphylococcal biofilm activity of miconazoctylium bromide.. Org Biomol Chem. 2018;16(23):42884294. doi:10.1039/c8ob00897c

Related Elements

Bromine

35 Br 79.904000000 Bromine

See more Bromine products. Bromine (atomic symbol: Br, atomic number: 35) is a Block P, Group 17, Period 4 element. Its electron configuration is [Ar]4s²3d¹⁰4p⁵. The bromine atom has a radius of 102 pm and its Van der Waals radius is 183 pm. In its elemental form, bromine has a red-brown appearance. Bromine does not occur by itself in nature; it is found as colorless soluble crystalline mineral halide salts. Bromine was discovered and first isolated by Antoine Jérôme Balard and Leopold Gmelin in 1825-1826.