Auxiliary-Assisted Palladium-Catalyzed Direct C(sp(3))-H Sulfonamidation To Afford 1,2-Amino Alcohol Derivatives.

Title Auxiliary-Assisted Palladium-Catalyzed Direct C(sp(3))-H Sulfonamidation To Afford 1,2-Amino Alcohol Derivatives.
Authors Y. Dong; G. Liu
Journal J Org Chem
DOI 10.1021/acs.joc.6b02975
Abstract

An auxiliary-assisted Pd-catalyzed C(sp(3))-H sulfonamidation approach using NFSI as both nitrogen source and oxidant to afford 1,2-amino alcohol derivatives is described in this paper. This method is novel and attractive because of its high yields, wide range of substrate scopes, and good tolerance for many functional groups. Oximido and sulfonyl group can be removed with this method.

Citation Y. Dong; G. Liu.Auxiliary-Assisted Palladium-Catalyzed Direct C(sp(3))-H Sulfonamidation To Afford 1,2-Amino Alcohol Derivatives.. J Org Chem. 2017;82(7):38643872. doi:10.1021/acs.joc.6b02975

Related Elements

Palladium

46 Pd 106.420000000 Palladium

Palladium Bohr ModelSee more Palladium products. Palladium (atomic symbol: Pd, atomic number: 46) is a Block D, Group 10, Period 5 element with an atomic weight of 106.42. The number of electrons in each of palladium's shells is 2, 8, 18, 18 and its electron configuration is [Kr] 4d10. The palladium atom has a radius of 137 pm and a Van der Waals radius of 202 pm. In its elemental form, palladium has a silvery white appearance. Palladium is a member of the platinum group of metals (along with platinum, rhodium, ruthenium, iridium and osmium). Elemental PalladiumPalladium has the lowest melting point and is the least dense of the group. Palladium can be found as a free metal and alloyed with other platinum-group metals. Nickel-copper deposits are the main commercial source of palladium. Palladium was discovered and first isolated by William Hyde Wollaston in 1803. Its name is derived from the asteroid Pallas.

Related Forms & Applications

Organometallics
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