Biomimetic apatite formed on cobalt-chromium alloy: A polymer-free carrier for drug eluting stent.

Title Biomimetic apatite formed on cobalt-chromium alloy: A polymer-free carrier for drug eluting stent.
Authors C. Chen; C. Yao; J. Yang; D. Luo; X. Kong; S.M. Chung; I.S. Lee
Journal Colloids Surf B Biointerfaces
DOI 10.1016/j.colsurfb.2016.12.021
Abstract

In this study, sirolimus (SRL) was loaded within biomimetic apatite formed on cobalt-chromium (Co-Cr) alloy, which has been reported for the first time, to inhibit the in-stent restenosis. Two different groups of loading SRL within biomimetic apatite were prepared: Group A (mono-layer of apatite/SRL) and Group B (bi-layer of apatite/SRL). Group A and Group B showed the biphasic pattern of SRL release up to 40 and 90days, respectively. The attachment of human artery smooth muscle cell (HASMC) for both Group A and Group B was significantly inhibited, and proliferation dramatically decreased with the release of SRL. Noteworthily, biomimetic apatite alone also suppressed the SMC proliferation. The porous biomimetic apatite uniformly covered Co-Cr stent without crack or webbings. After balloon expansion, the integrity of biomimetic apatite was sufficient to resist delamination or destruction. Thus, this study demonstrated that biomimetic apatite is a promising drug carrier for potential use in stents.

Citation C. Chen; C. Yao; J. Yang; D. Luo; X. Kong; S.M. Chung; I.S. Lee.Biomimetic apatite formed on cobalt-chromium alloy: A polymer-free carrier for drug eluting stent.. Colloids Surf B Biointerfaces. 2017;151:156164. doi:10.1016/j.colsurfb.2016.12.021

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Cobalt

See more Cobalt products. Cobalt (atomic symbol: Co, atomic number: 27) is a Block D, Group 9, Period 4 element with an atomic weight of 58.933195. Cobalt Bohr ModelThe number of electrons in each of cobalt's shells is 2, 8, 15, 2 and its electron configuration is [Ar]3d7 4s2. The cobalt atom has a radius of 125 pm and a Van der Waals radius of 192 pm. Cobalt was first discovered by George Brandt in 1732. In its elemental form, cobalt has a lustrous gray appearance. Cobalt is found in cobaltite, erythrite, glaucodot and skutterudite ores. Elemental CobaltCobalt produces brilliant blue pigments which have been used since ancient times to color paint and glass. Cobalt is a ferromagnetic metal and is used primarily in the production of magnetic and high-strength superalloys. Co-60, a commercially important radioisotope, is useful as a radioactive tracer and gamma ray source. The origin of the word Cobalt comes from the German word "Kobalt" or "Kobold," which translates as "goblin," "elf" or "evil spirit.

Chromium

See more Chromium products. Chromium (atomic symbol: Cr, atomic number: 24) is a Block D, Group 6, Period 4 element with an atomic weight of 51.9961. Chromium Bohr ModelThe number of electrons in each of Chromium's shells is 2, 8, 13, 1 and its electron configuration is [Ar] 3d5 4s1. Louis Nicolas Vauquelin first discovered chromium in 1797 and first isolated it the following year. The chromium atom has a radius of 128 pm and a Van der Waals radius of 189 pm. In its elemental form, chromium has a lustrous steel-gray appearance. Elemental ChromiumChromium is the hardest metallic element in the periodic table and the only element that exhibits antiferromagnetic ordering at room temperature, above which it transforms into a paramagnetic solid. The most common source of chromium is chromite ore (FeCr2O4). Due to its various colorful compounds, Chromium was named after the Greek word 'chroma.' meaning color.

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