Biosynthesis of cerium oxide nanoparticles and their effect on lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction in male Sprague Dawley rats.

Title Biosynthesis of cerium oxide nanoparticles and their effect on lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction in male Sprague Dawley rats.
Authors G. Chen; Y. Xu
Journal Mater Sci Eng C Mater Biol Appl
DOI 10.1016/j.msec.2017.11.014
Abstract

The fetal/life challenging Sepsis is an urgent medical disaster which have developed "blood poisoning". The sepsis is one of the disorders of organs which cause death in patients. The investigational models that mimicchemical change of sepsis in human bodywereessential. We have synthesized CeO2 NPs using eco-friendly method using plant extract. The characterization of synthesized CeO2 NPs was studied using UV-Vis, FTIR, XRD, SEM, EDX and TEM analysis. The results were confirmed that the synthesized CeO2 was in nano size with spherical shape. The synthesized CeO2 nanoparticles were evaluated against lipopolysaccharide (LPS) male Sprague Dawley rats. We have intravenously administrated CeO2NPs (0.5mg/kg) to Sprague Dawleyratswhich are septic and checked the death rate, respiratory rate, blood pressure, body temperature. The rats could restore all parameters with decrease in hepatic damage, serum cytokines/chemokines, and swelling indicators. The Kupffer cells and macrophage cells treated with CeO2NPs and showed lowest TNF-a, IL-1b, IL-6, and HMGB1release. Due to the ROS, iNOS, COX-2, and nuclear factor-kappa light chain, the triggered B cells (NF-kB) transcriptional action was decreased. Thus, results represents that CeO2NPs can be applied as healing agent for liver sepsis.

Citation G. Chen; Y. Xu.Biosynthesis of cerium oxide nanoparticles and their effect on lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction in male Sprague Dawley rats.. Mater Sci Eng C Mater Biol Appl. 2018;83:148153. doi:10.1016/j.msec.2017.11.014

Related Elements

Cerium

58 Ce 140.116000000 Cerium

See more Cerium products. Cerium (atomic symbol: Ce, atomic number: 58) is a Block F, Group 3, Period 6 element with an atomic weight of 140.116. The number of electrons in each of cerium's shells is 2, 8, 18, 19, 9, 2 and its electron configuration is [Xe]4f2 6s2. Cerium Bohr ModelThe cerium atom has a radius of 182.5 pm and a Van der Waals radius of 235 pm. In its elemental form, cerium has a silvery white appearance. Cerium is the most abundant of the rare earth metals. It is characterized chemically by having two valence states, the +3 cerous and +4 ceric states. The ceric state is the only non-trivalent rare earth ion stable in aqueous solutions. Elemental CeriumIt is therefore strongly acidic and oxidizing, in addition to being moderately toxic.The cerous state closely resembles the other trivalent rare earths. Cerium is found in the minerals allanite, bastnasite, hydroxylbastnasite, monazite, rhabdophane, synchysite and zircon. Cerium was discovered by Martin Heinrich Klaproth, Jöns Jakob Berzelius, and Wilhelm Hisinger in 1803 and first isolated by Carl Gustaf Mosander in 1839. The element was named after the asteroid Ceres, which itself was named after the Roman god of agriculture.

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Nanomaterials Oxides
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