Effects of vanillin on potassium bromate-induced neurotoxicity in adult mice: impact on behavior, oxidative stress, genes expression, inflammation and fatty acid composition.

Title Effects of vanillin on potassium bromate-induced neurotoxicity in adult mice: impact on behavior, oxidative stress, genes expression, inflammation and fatty acid composition.
Authors H. Ben Saad; N. Kharrat; D. Driss; M. Gargouri; R. Marrakchi; K. Jammoussi; C. Magné; T. Boudawara; S.Ellouz Chaabouni; K.Mounir Zeghal; A. Hakim; I. Ben Amara
Journal Arch Physiol Biochem
DOI 10.1080/13813455.2017.1283527
Abstract

CONTEXT: Vanillin is known to possess important antioxidant activity.

OBJECTIVE: The current study was conducted to establish the therapeutic efficiency of vanillin against potassium bromate (KBrO3)-induced depression-like behavior and oxidative stress in mice.

MATERIAL AND METHODS: Mice were exposed during 15 days either to potassium bromate (KBrO3), KBrO3+?vanillin or to only vanillin.

RESULTS: Our results revealed a significant modification in the fatty acid composition of the KBrO3-treated mice. In addition, KBrO3 induced a significant reduction in enzymatic activities and gene expressions, Na(+)?-K(+?) and Mg(2+)-ATPases, acetylcholinesterase and butylcholinesterase activities. The gene expression of tumor necrosis factor-?, interleukin-1?, interleukin-6 and COX2, significantly increased in the cerebrum of KBrO3-treated group. Histopathological observations were consistent with these effects. Co-treatment with vanillin significantly attenuated KBrO3-induced oxidative stress and inflammation.

CONCLUSION: This work suggests that vanillin mitigates KBrO3-induced depression, and that this neuroprotective effect proceeds through anti-oxidant and anti-inflammatory activities.

Citation H. Ben Saad; N. Kharrat; D. Driss; M. Gargouri; R. Marrakchi; K. Jammoussi; C. Magné; T. Boudawara; S.Ellouz Chaabouni; K.Mounir Zeghal; A. Hakim; I. Ben Amara.Effects of vanillin on potassium bromate-induced neurotoxicity in adult mice: impact on behavior, oxidative stress, genes expression, inflammation and fatty acid composition.. Arch Physiol Biochem. 2017;123(3):165174. doi:10.1080/13813455.2017.1283527

Related Elements

Potassium

Elemental PotassiumSee more Potassium products. Potassium (atomic symbol: K, atomic number: 19) is a Block S, Group 1, Period 4 element with an atomic weight of 39.0983. The number of electrons in each of Potassium's shells is [2, 8, 8, 1] and its electron configuration is [Ar] 4s1. The potassium atom has a radius of 227.2 pm and a Van der Waals radius of 275 pm. Potassium was discovered and first isolated by Sir Humphrey Davy in 1807. Potassium is the seventh most abundant element on earth. It is one of the most reactive and electropositive of all metals and rapidly oxidizes. As with other alkali metals, potassium decomposes in water with the evolution of hydrogen because of its reacts violently with water, it only occurs in nature in ionic salts.Potassium Bohr Model In its elemental form, potassium has a silvery gray metallic appearance, but its compounds (such as potassium hydroxide) are more frequently used in industrial and chemical applications. The origin of the element's name comes from the English word 'potash,' meaning pot ashes, and the Arabic word qali, which means alkali. The symbol K originates from the Latin word kalium.

Bromine

See more Bromine products. Bromine (atomic symbol: Br, atomic number: 35) is a Block P, Group 17, Period 4 element. Its electron configuration is [Ar]4s23d104p5. The bromine atom has a radius of 102 pm and its Van der Waals radius is 183 pm. In its elemental form, bromine Bromine Bohr Model has a red-brown appearance. Bromine does not occur by itself in nature; it is found as colorless soluble crystalline mineral halide salts. Bromine was discovered and first isolated by Antoine Jérôme Balard and Leopold Gmelin in 1825-1826.

Related Forms & Applications