Electroreductive 4-Pyridylation of Electron-deficient Alkenes with Assistance of Ni(acac)2.

Title Electroreductive 4-Pyridylation of Electron-deficient Alkenes with Assistance of Ni(acac)2.
Authors S. Zhang; L. Li; X. Li; J. Zhang; K. Xu; G. Li; M. Findlater
Journal Org Lett
DOI 10.1021/acs.orglett.0c01014
Abstract

An electroreductive 4-pyridylation of activated alkenes was developed in an undivided cell with the assistance of Ni(acac) (acac = acetylacetone). This novel protocol is compatible with a broad range of electron-poor alkenes, which are commonly regarded as challenging substrates in the previous conventional approaches. Moreover, a series of cyclic voltammetric experiments were conducted to reveal the unique role of Ni(acac) differentiating reduction process of reaction partners.

Citation S. Zhang; L. Li; X. Li; J. Zhang; K. Xu; G. Li; M. Findlater.Electroreductive 4-Pyridylation of Electron-deficient Alkenes with Assistance of Ni(acac)2.. Org Lett. 2020;22(9):35703575. doi:10.1021/acs.orglett.0c01014

Related Elements

Nickel

See more Nickel products. Nickel (atomic symbol: Ni, atomic number: 28) is a Block D, Group 4, Period 4 element with an atomic weight of 58.6934. Nickel Bohr ModelThe number of electrons in each of nickel's shells is [2, 8, 16, 2] and its electron configuration is [Ar]3d8 4s2. Nickel was first discovered by Alex Constedt in 1751. The nickel atom has a radius of 124 pm and a Van der Waals radius of 184 pm. In its elemental form, nickel has a lustrous metallic silver appearance. Nickel is a hard and ductile transition metal that is considered corrosion-resistant because of its slow rate of oxidation. Elemental NickelIt is one of four elements that are ferromagnetic and is used in the production of various type of magnets for commercial use. Nickel is sometimes found free in nature but is more commonly found in ores. The bulk of mined nickel comes from laterite and magmatic sulfide ores. The name originates from the German word kupfernickel, which means "false copper" from the illusory copper color of the ore.

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