Facile meltPEGylation of flame-made luminescent Tb-doped yttrium oxide particles: hemocompatibility, cellular uptake and comparison to silica.

Title Facile meltPEGylation of flame-made luminescent Tb-doped yttrium oxide particles: hemocompatibility, cellular uptake and comparison to silica.
Authors K. Keevend; G. Panzarasa; F.H.L. Starsich; M. Zeltner; A. Spyrogianni; E. Tsolaki; G. Fortunato; S.E. Pratsinis; S. Bertazzo; I.K. Herrmann
Journal Chem Commun (Camb)
DOI 10.1039/c7cc09402g
Abstract

Flame aerosol technology is a versatile method for scalable synthesis of nanoparticles. Since particles are produced and collected in a dry state, dispersibility and further functionalization could pose hurdles to their biomedical use. We report on a one-pot, scalable and robust procedure for the PEGylation of flame-made yttria and silica nanoparticles. We demonstrate improved colloidal stability, attenuated activation of blood coagulation and decreased uptake into phagocytic cells, all of which pave the way for facilitated biomedical use of flame-made oxide nanoparticles.

Citation K. Keevend; G. Panzarasa; F.H.L. Starsich; M. Zeltner; A. Spyrogianni; E. Tsolaki; G. Fortunato; S.E. Pratsinis; S. Bertazzo; I.K. Herrmann.Facile meltPEGylation of flame-made luminescent Tb-doped yttrium oxide particles: hemocompatibility, cellular uptake and comparison to silica.. Chem Commun (Camb). 2018. doi:10.1039/c7cc09402g

Related Elements

Yttrium

See more Yttrium products. Yttrium (atomic symbol: Y, atomic number: 39) is a Block D, Group 3, Period 5 element with an atomic weight of 88.90585. Yttrium Bohr ModelThe number of electrons in each of yttrium's shells is [2, 8, 18, 9, 2] and its electron configuration is [Kr] 4d1 5s2. The yttrium atom has a radius of 180 pm and a Van der Waals radius of 219 pm. Yttrium was discovered by Johann Gadolin in 1794 and first isolated by Carl Gustav Mosander in 1840. In its elemental form, Yttrium has a silvery white metallic appearance. Yttrium has the highest thermodynamic affinity for oxygen of any element. Elemental YttriumYttrium is not found in nature as a free element and is almost always found combined with the lanthanides in rare earth minerals. While not part of the rare earth series, it resembles the heavy rare earths which are sometimes referred to as the "yttrics" for this reason. Another unique characteristic derives from its ability to form crystals with useful properties. The name yttrium originated from a Swedish village near Vaxholm called Yttbery where it was discovered.

Terbium

See more Terbium products. Terbium (atomic symbol: Tb, atomic number: 65) is a Block F, Group 3, Period 6 element with an atomic radius of 158.92535.Terbium Bohr Model The number of electrons in each of Terbium's shells is [2, 8, 18, 27, 8, 2] and its electron configuration is [Xe]4f9 6s2. The terbium atom has a radius of 177 pm and a Van der Waals radius of 221 pm.Terbium was discovered and first isolated by Carl Gustaf Mosander in 1842. In its elemental form, terbium is a silvery-white soft metal. Terbium is found in cerite, gadolinite, and monazite. It is not found in nature as a free element. Elemental TerbiumTerbium compounds are brightly fluorescent, and a majority of the world's terbium supply is used for creating green phosphors that enable trichromatic lighting technology. It is also frequently used as a dopant for crystalline solid-state devices and fuel cell materials. It is named after Ytterby, the town in Sweden where it was discovered.

Silicon

See more Silicon products. Silicon (atomic symbol: Si, atomic number: 14) is a Block P, Group 14, Period 3 element with an atomic weight of 28.085. Silicon Bohr MoleculeThe number of electrons in each of Silicon's shells is 2, 8, 4 and its electron configuration is [Ne] 3s2 3p2. The silicon atom has a radius of 111 pm and a Van der Waals radius of 210 pm. Silicon was discovered and first isolated by Jöns Jacob Berzelius in 1823. Silicon makes up 25.7% of the earth's crust, by weight, and is the second most abundant element, exceeded only by oxygen. The metalloid is rarely found in pure crystal form and is usually produced from the iron-silicon alloy ferrosilicon. Elemental SiliconSilica (or silicon dioxide), as sand, is a principal ingredient of glass, one of the most inexpensive of materials with excellent mechanical, optical, thermal, and electrical properties. Ultra high purity silicon can be doped with boron, gallium, phosphorus, or arsenic to produce silicon for use in transistors, solar cells, rectifiers, and other solid-state devices which are used extensively in the electronics industry.The name Silicon originates from the Latin word silex which means flint or hard stone.

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