Magnetic-luminescent cerium-doped gadolinium aluminum garnet nanoparticles for simultaneous imaging and photodynamic therapy of cancer cells.

Title Magnetic-luminescent cerium-doped gadolinium aluminum garnet nanoparticles for simultaneous imaging and photodynamic therapy of cancer cells.
Authors A. Jain; R. Koyani; C. Muñoz; P. Sengar; O.E. Contreras; P. Juárez; G.A. Hirata
Journal J Colloid Interface Sci
DOI 10.1016/j.jcis.2018.04.100
Abstract

Nanoparticle (NP) and photosensitizer (PS) conjugates capable of X-ray photodynamic therapy (X-PDT) are a research focus due to their potential applications in cancer treatment. Combined with X-PDT, appropriate imaging properties of the nanocomposite will make it suitable for theranostics of deep lying tumors. In this work, we describe the development of magnetic-luminescent GdCeAlO nanoparticles (GAG) coated with mesoporous silica (mSiO) and loaded with rose bengal (RB) to yield a nanocomposite GAG@mSiO@RB capable of X-PDT. GAG nanoparticles were synthesized using the sol-gel method. The synthesized GAG nanoparticles showed a strong visible yellow emission with a quantum yield of ?32%. Moreover, the broad emission spectra of GAG nanoparticles centered at 585?nm showed a good overlap with the absorption of RB. Upon irradiation with X-rays (55?KV), the GAG@mSiO@RB nanocomposite produced significantly higher singlet oxygen compared with RB alone, as confirmed by the 1,2-diphenylisobenzofuran (DPBF) assay. The developed GAG@mSiO@RB nanocomposite significantly reduced the viability of human breast cancer (MDA-MB-231) cells upon irradiation with blue light (??=?470?nm). The calculated LC of GAG@mSiO@RB nanocomposites were 26.69, 11.2, and 6.56?µg/mL at a dose of ?0.16, 0.33 and 0.5?J/cm, respectively. Moreover, the nanocomposite showed paramagnetic properties with high magnetic mass susceptibility which are useful for high contrast T weighted magnetic resonance imaging (MRI). Together with X-PDT, the paramagnetic properties of the proposed GAG@mSiO@RB nanocomposite system are promising for their future application in simultaneous detection and treatment of deep-lying tumors.

Citation A. Jain; R. Koyani; C. Muñoz; P. Sengar; O.E. Contreras; P. Juárez; G.A. Hirata.Magnetic-luminescent cerium-doped gadolinium aluminum garnet nanoparticles for simultaneous imaging and photodynamic therapy of cancer cells.. J Colloid Interface Sci. 2018;526:220229. doi:10.1016/j.jcis.2018.04.100

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See more Gadolinium products. Gadolinium (atomic symbol: Gd, atomic number: 64) is a Block F, Group 3, Period 6 element with an atomic radius of 157.25. Gadolinium Bohr ModelThe number of electrons in each of Gadolinium's shells is [2, 8, 18, 25, 9, 2] and its electron configuration is [Xe] 4f7 5d1 6s2. The gadolinium atom has a radius of 180 pm and a Van der Waals radius of 237 pm. Gadolinium was discovered by Jean Charles Galissard de Marignac in 1880 and first isolated by Lecoq de Boisbaudran in 1886. In its elemental form, gadolinium has a silvery-white appearance. Gadolinium is a rare earth or lanthanide element that possesses unique properties advantageous to specialized applications such as semiconductor fabrication and nuclear reactor shielding. Elemental Gadolinium PictureIt is utilized for both its high magnetic moment (7.94μ B) and in phosphors and scintillator crystals. When complexed with EDTA ligands, it is used as an injectable contrast agent for MRIs. The element is named after the Finnish chemist and geologist Johan Gadolin.

Cerium

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