Oil/water nano-emulsion loaded with cobalt ferrite oxide nanocubes for photo-acoustic and magnetic resonance dual imaging in cancer: in vitro and preclinical studies.

Title Oil/water nano-emulsion loaded with cobalt ferrite oxide nanocubes for photo-acoustic and magnetic resonance dual imaging in cancer: in vitro and preclinical studies.
Authors R. Vecchione; V. Quagliariello; P. Giustetto; D. Calabria; A. Sathya; R. Marotta; M. Profeta; S. Nitti; N. Silvestri; T. Pellegrino; R.V. Iaffaioli; P.Antonio Netti
Journal Nanomedicine
DOI 10.1016/j.nano.2016.08.022
Abstract

Dual imaging dramatically improves detection and early diagnosis of cancer. In this work we present an oil in water (O/W) nano-emulsion stabilized with lecithin and loaded with cobalt ferrite oxide (Co0.5Fe2.5O4) nanocubes for photo-acoustic and magnetic resonance dual imaging. The nanocarrier is responsive in in vitro photo-acoustic and magnetic resonance imaging (MRI) tests. A clear and significant time-dependent accumulation in tumor tissue is shown in in vivo photo-acoustic studies on a murine melanoma xenograft model. The proposed O/W nano-emulsion exhibits also high values of r2/r1 (ranging from 45 to 85, depending on the magnetic field) suggesting a possible use as T2 weighted image contrast agents. In addition, viability and cellular uptake studies show no significant cytotoxicity on the fibroblast cell line. We also tested the O/W nano-emulsion loaded with curcumin against melanoma cancer cells demonstrating a significant cytotoxicity and thus showing possible therapeutic effects in addition to the in vivo imaging.

Citation R. Vecchione; V. Quagliariello; P. Giustetto; D. Calabria; A. Sathya; R. Marotta; M. Profeta; S. Nitti; N. Silvestri; T. Pellegrino; R.V. Iaffaioli; P.Antonio Netti.Oil/water nano-emulsion loaded with cobalt ferrite oxide nanocubes for photo-acoustic and magnetic resonance dual imaging in cancer: in vitro and preclinical studies.. Nanomedicine. 2016;13(1):275286. doi:10.1016/j.nano.2016.08.022

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Iron

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