Optimized anion exchange column isolation of zirconium-89 (Zr) from yttrium cyclotron target: Method development and implementation on an automated fluidic platform.

Title Optimized anion exchange column isolation of zirconium-89 (Zr) from yttrium cyclotron target: Method development and implementation on an automated fluidic platform.
Authors M.J. O'Hara; N.J. Murray; J.C. Carter; S.S. Morrison
Journal J Chromatogr A
DOI 10.1016/j.chroma.2018.02.053
Abstract

Zirconium-89 (Zr), produced by the (p, n) reaction from naturally monoisotopic yttrium (Y), is a promising positron emitting isotope for immunoPET imaging. Its long half-life of 78.4?h is sufficient for evaluating slow physiological processes. A prototype automated fluidic system, coupled to on-line and in-line detectors, has been constructed to facilitate development of new Zr purification methodologies. The highly reproducible reagent delivery platform and near-real time monitoring of column effluents allows for efficient method optimization. The separation of Zr from dissolved Y metal targets was evaluated using several anion exchange resins. Each resin was evaluated against its ability to quantitatively capture Zr from a load solution high in dissolved Y. The most appropriate anion exchange resin for this application was identified, and the separation method was optimized. The method is capable of a high Y decontamination factor (>10) and has been shown to remove Fe, an abundant contaminant in Y foils, from the Zr elution fraction. Finally, the method was evaluated using cyclotron bombarded Y foil targets; the method was shown to achieve >95% recovery of the Zr present in the foils. The anion exchange column method described here is intended to be the first Zr isolation stage in a dual-column purification process.

Citation M.J. O'Hara; N.J. Murray; J.C. Carter; S.S. Morrison.Optimized anion exchange column isolation of zirconium-89 (Zr) from yttrium cyclotron target: Method development and implementation on an automated fluidic platform.. J Chromatogr A. 2018;1545:4858. doi:10.1016/j.chroma.2018.02.053

Related Elements

Zirconium

40 Zr 91.224000000 Zirconium

See more Zirconium products. Zirconium (atomic symbol: Zr, atomic number: 40) is a Block D, Group 4, Period 5 element with an atomic weight of 91.224. Zirconium Bohr ModelThe number of electrons in each of Zirconium's shells is 2, 8, 18, 10, 2 and its electron configuration is [Kr]4d2 5s2. The zirconium atom has a radius of 160 pm and a Van der Waals radius of 186 pm. Zirconium was discovered by Martin Heinrich Klaproth in 1789 and first isolated by Jöns Jakob Berzelius in 1824. In its elemental form, zirconium has a silvery white appearance that is similar to titanium. Zirconium's principal mineral is zircon (zirconium silicate). Elemental ZirconiumZirconium is commercially produced as a byproduct of titanium and tin mining and has many applications as a opacifier and a refractory material. It is not found in nature as a free element. The name of zirconium comes from the mineral zircon, the most important source of zirconium, and from the Persian wordzargun, meaning gold-like.

Yttrium

39 Y 88.905850000 Yttrium

See more Yttrium products. Yttrium (atomic symbol: Y, atomic number: 39) is a Block D, Group 3, Period 5 element with an atomic weight of 88.90585. Yttrium Bohr ModelThe number of electrons in each of yttrium's shells is [2, 8, 18, 9, 2] and its electron configuration is [Kr] 4d1 5s2. The yttrium atom has a radius of 180 pm and a Van der Waals radius of 219 pm. Yttrium was discovered by Johann Gadolin in 1794 and first isolated by Carl Gustav Mosander in 1840. In its elemental form, Yttrium has a silvery white metallic appearance. Yttrium has the highest thermodynamic affinity for oxygen of any element. Elemental YttriumYttrium is not found in nature as a free element and is almost always found combined with the lanthanides in rare earth minerals. While not part of the rare earth series, it resembles the heavy rare earths which are sometimes referred to as the "yttrics" for this reason. Another unique characteristic derives from its ability to form crystals with useful properties. The name yttrium originated from a Swedish village near Vaxholm called Yttbery where it was discovered.

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