Production of Zr-89 using sputtered yttrium coin targets (89)Zr using sputtered yttrium coin targets.

Title Production of Zr-89 using sputtered yttrium coin targets (89)Zr using sputtered yttrium coin targets.
Authors S.Lee Queern; T.Aramide Aweda; A.Vidal Fern Massicano; N.Ashby Clanton; R.El Sayed; J.Andrew Sader; A. Zyuzin; S.Elizabeth Lapi
Journal Nucl Med Biol
DOI 10.1016/j.nucmedbio.2017.03.004
Abstract

An increasing interest in zirconium-89 ((89)Zr) can be attributed to the isotope's half-life which is compatible with antibody imaging using positron emission tomography (PET). The goal of this work was to develop an efficient means of production for (89)Zr that provides this isotope with high radionuclidic purity and specific activity. We investigated the irradiation of yttrium sputtered niobium coins and compared the yields and separation efficiency to solid yttrium coins. The sputtered coins were irradiated with an incident beam energy of 17.5MeV or 17.8MeV providing a degraded transmitted energy through an aluminum degrader of 12.5MeV or 12.8MeV, respectively, with various currents to determine optimal cyclotron conditions for (89)Zr production. Dissolution of the solid yttrium coin took 2h with 50mL of 2M HCl and dissolution of the sputtered coin took 15-30min with 4mL of 2M HCl. During the separation of (89)Zr from the solid yttrium coins, 77.9 ± 11.2% of the activity was eluted off in an average of 7.3mL of 1M oxalic acid whereas for the sputtered coins, 91 ± 6% was eluted off in an average of 1.2mL of 1M oxalic acid with 100% radionuclidic purity. The effective specific activity determined via DFO-SCN titration from the sputtered coins was 108±7mCi/?mol as compared to 20.3mCi/?mol for the solid yttrium coin production. ICP-MS analysis of the yttrium coin and the sputtered coins showed 99.99% yttrium removed with 178?g of yttrium in the final solution and 99.93-100% of yttrium removed with remaining range of 0-42?g of yttrium in the final solution, respectively. The specific activity calculated for the solid coin and 3 different sputtered coins using the concentration of Zr found via ICP-MS was 140±2mCi/?mol, 300±30mCi/?mol, 410±60mCi/?mol and 1719±5mCi/?mol, respectively. Labeling yields of the (89)Zr produced via sputtered targets for (89)Zr- DFO-trastuzumab were >98%. Overall, these results show the irradiation of yttrium sputtered niobium coins is a highly effective means for the production of (89)Zr.

Citation S.Lee Queern; T.Aramide Aweda; A.Vidal Fern Massicano; N.Ashby Clanton; R.El Sayed; J.Andrew Sader; A. Zyuzin; S.Elizabeth Lapi.Production of Zr-89 using sputtered yttrium coin targets (89)Zr using sputtered yttrium coin targets.. Nucl Med Biol. 2017;50:1116. doi:10.1016/j.nucmedbio.2017.03.004

Related Elements

Yttrium

39 Y 88.905850000 Yttrium

See more Yttrium products. Yttrium (atomic symbol: Y, atomic number: 39) is a Block D, Group 3, Period 5 element with an atomic weight of 88.90585. Yttrium Bohr ModelThe number of electrons in each of yttrium's shells is [2, 8, 18, 9, 2] and its electron configuration is [Kr] 4d1 5s2. The yttrium atom has a radius of 180 pm and a Van der Waals radius of 219 pm. Yttrium was discovered by Johann Gadolin in 1794 and first isolated by Carl Gustav Mosander in 1840. In its elemental form, Yttrium has a silvery white metallic appearance. Yttrium has the highest thermodynamic affinity for oxygen of any element. Elemental YttriumYttrium is not found in nature as a free element and is almost always found combined with the lanthanides in rare earth minerals. While not part of the rare earth series, it resembles the heavy rare earths which are sometimes referred to as the "yttrics" for this reason. Another unique characteristic derives from its ability to form crystals with useful properties. The name yttrium originated from a Swedish village near Vaxholm called Yttbery where it was discovered.

Zirconium

40 Zr 91.224000000 Zirconium

See more Zirconium products. Zirconium (atomic symbol: Zr, atomic number: 40) is a Block D, Group 4, Period 5 element with an atomic weight of 91.224. Zirconium Bohr ModelThe number of electrons in each of Zirconium's shells is 2, 8, 18, 10, 2 and its electron configuration is [Kr]4d2 5s2. The zirconium atom has a radius of 160 pm and a Van der Waals radius of 186 pm. Zirconium was discovered by Martin Heinrich Klaproth in 1789 and first isolated by Jöns Jakob Berzelius in 1824. In its elemental form, zirconium has a silvery white appearance that is similar to titanium. Zirconium's principal mineral is zircon (zirconium silicate). Elemental ZirconiumZirconium is commercially produced as a byproduct of titanium and tin mining and has many applications as a opacifier and a refractory material. It is not found in nature as a free element. The name of zirconium comes from the mineral zircon, the most important source of zirconium, and from the Persian wordzargun, meaning gold-like.

Related Forms & Applications

Sputtering Targets
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