Radiosensitization of Prostate Cancers In Vitro and In Vivo to Erbium-filtered Orthovoltage X-rays Using Actively Targeted Gold Nanoparticles.

Title Radiosensitization of Prostate Cancers In Vitro and In Vivo to Erbium-filtered Orthovoltage X-rays Using Actively Targeted Gold Nanoparticles.
Authors A.M. Khoo; S.Hyun Cho; F.J. Reynoso; M. Aliru; K. Aziz; M. Bodd; X. Yang; M.F. Ahmed; S. Yasar; N. Manohar; J. Cho; R. Tailor; H.D. Thames; S. Krishnan
Journal Sci Rep
DOI 10.1038/s41598-017-18304-y
Abstract

Theoretical investigations suggest that gold nanoparticle (GNP)-mediated radiation dose enhancement and radiosensitization can be maximized when photons interact with gold, predominantly via photoelectric absorption. This makes ytterbium (Yb)-169, which emits photons with an average energy of 93?keV (just above the K-edge of gold), an ideal radioisotope for such purposes. This investigation tests the feasibility of tumor-specific prostate brachytherapy achievable with Yb-169 and actively targeted GNPs, using an external beam surrogate of Yb-169 created from an exotic filter material - erbium (Er) and a standard copper-filtered 250?kVp beam. The current in vitro study shows that treatment of prostate cancer cells with goserelin-conjugated gold nanorods (gGNRs) promotes gonadotropin releasing hormone receptor-mediated internalization and enhances radiosensitivity to both Er-filtered and standard 250?kVp beams, 14 and 10%, respectively. While the degree of GNP-mediated radiosensitization as seen from the in vitro study may be considered moderate, the current in vivo study shows that gGNR treatment plus Er-filtered x-ray irradiation is considerably more effective than radiation treatment alone (p?

Citation A.M. Khoo; S.Hyun Cho; F.J. Reynoso; M. Aliru; K. Aziz; M. Bodd; X. Yang; M.F. Ahmed; S. Yasar; N. Manohar; J. Cho; R. Tailor; H.D. Thames; S. Krishnan.Radiosensitization of Prostate Cancers In Vitro and In Vivo to Erbium-filtered Orthovoltage X-rays Using Actively Targeted Gold Nanoparticles.. Sci Rep. 2017;7(1):18044. doi:10.1038/s41598-017-18304-y

Related Elements

Erbium

See more Erbium products. Erbium (atomic symbol: Er, atomic number: 68) is a Block F, Group 3, Period 6 element with an atomic radius of 167.259. Erbium Bohr ModelThe number of electrons in each of Erbium's shells is [2, 8, 18, 30, 8, 2] and its electron configuration is [Xe]4f12 6s2. The erbium atom has a radius of 176 pm and a Van der Waals radius of 235 pm. Erbium was discovered by Carl Mosander in 1843. Sources of Erbium include the mineral monazite and sand ores. Erbium is a member of the lanthanide or rare earth series of elements.Elemental Erbium Picture In its elemental form, erbium is soft and malleable. It is fairly stable in air and does not oxidize as rapidly as some of the other rare earth metals. Erbium's ions fluoresce in a bright pink color, making them highly useful for imaging and optical applications. It is named after the Swedish town Ytterby where it was first discovered.

Gold

See more Gold products. Gold (atomic symbol: Au, atomic number: 79) is a Block D, Group 11, Period 6 element with an atomic weight of 196.966569. The number of electrons in each of Gold's shells is 2, 8, 18, 32, 18, 1 and its electron configuration is [Xe]4f142 5d10 6s1. Gold Bohr ModelThe gold atom has a radius of 144 pm and a Van der Waals radius of 217 pm. Gold was first discovered by Early Man prior to 6000 B.C. In its elemental form, gold has a metallic yellow appearance. Gold is a soft metal and is usually alloyed to give it more strength.Elemental Gold It is a good conductor of heat and electricity, and is unaffected by air and most reagents. It is one of the least reactive chemical elements. Gold is often found as a free element and with silver as a gold-silver alloy. Less commonly, it is found in minerals as gold compounds, usually with tellurium.

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