Neodymium Oxide Induces Cytotoxicity and Activates NF-κB and Caspase-3 in NR8383 Cells.

Title Neodymium Oxide Induces Cytotoxicity and Activates NF-κB and Caspase-3 in NR8383 Cells.
Authors Huang, L.Hua; Yang, H.; Su, X.; Gao, Y.Rong; Xue, H.Nan; Wang, S.Hua
Journal Biomed Environ Sci
DOI 10.3967/bes2017.010
Abstract

We investigated whether Nd2O3 treatment results in cytotoxicity and other underlying effects in rat NR8383 alveolar macrophages. Cell viability assessed by the MTT assay revealed that Nd2O3 was toxic in a dose-dependent manner, but not in a time-dependent manner. An ELISA analysis indicated that exposure to Nd2O3 caused cell damage and enhanced synthesis and release of inflammatory chemokines. A Western blot analysis showed that protein expression levels of caspase-3, nuclear factor-κB (NF-κB) and its inhibitor IκB increased significantly in response to Nd2O3 treatment. Both NF-κB and caspase-3 signaling were activated, suggesting that both pathways are involved in Nd2O3 cytotoxicity.

Citation Huang, L.Hua; Yang, H.; Su, X.; Gao, Y.Rong; Xue, H.Nan; Wang, S.Hua.Neodymium Oxide Induces Cytotoxicity and Activates NF-κB and Caspase-3 in NR8383 Cells..

Related Elements

Neodymium

60 Nd 144.242000000 Neodymium

See more Neodymium products. Neodymium (atomic symbol: Nd, atomic number: 60)is a Block F, Group 3, Period 6 element with an atomic weight of 144.242. Neodymium Bohr ModelThe number of electrons in each of Neodymium's shells is 2, 8, 18, 22, 8, 2 and its electron configuration is [Xe] 4f4 6s2. The neodymium atom has a radius of 181 pm and a Van der Waals radius of 229 pm. Neodymium was first discovered by Carl Aer von Welsbach in 1885. In its elemental form, neodymium has a silvery-white appearance. Neodymium is the most abundant of the rare earths after cerium and lanthanum. Neodymium is found in monazite and bastnäsite ores. It is used to make high-strength neodymium magnets and laser crystal substances like neodymium-doped yttrium aluminum garnet (also known as Nd:YAG). The name originates from the Greek words neos didymos, meaning new twin.

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