Praseodymium(III)-Catalyzed Regioselective Synthesis of C-N-Substituted Coumarins with Coumarins and Azides.

Title Praseodymium(III)-Catalyzed Regioselective Synthesis of C-N-Substituted Coumarins with Coumarins and Azides.
Authors Li, J.L.; Hu, D.C.; Liang, X.P.; Wang, Y.C.; Wang, H.S.; Pan, Y.M.
Journal J Org Chem
DOI 10.1021/acs.joc.7b01410
Abstract

A series of C-N-substituted coumarins were synthesized in good yields directly from coumarins and azides in the presence of Pr(OTf) without any additives or ligands needed. The selected compounds 3a, 3c-e, 3g, 3i, 3q, 3u, and 3v exhibited good anticancer activities against MGC-803, A549, and NCI-H460 cell lines with IC in the range 8.75-38.54 μmol L.

Citation Li, J.L.; Hu, D.C.; Liang, X.P.; Wang, Y.C.; Wang, H.S.; Pan, Y.M..Praseodymium(III)-Catalyzed Regioselective Synthesis of C-N-Substituted Coumarins with Coumarins and Azides..

Related Elements

Praseodymium

59 Pr 140.907650000 Praseodymium

See more Praseodymium products. Praseodymium (atomic symbol: Pr, atomic number: 59) is a Block F, Group 3, Period 6 element with an atomic weight of 140.90765. Praseodymium Bohr Model The number of electrons in each of praseodymium's shells is 2, 8, 18, 21, 8, 2 and its electron configuration is [Xe]4f3 6s2. The praseodymium atom has a radius of 182 pm and a Van der Waals radius of 239 pm. Praseodymium resembles the typical trivalent rare earths, however, it will exhibit a +4 state when stabilized in a zirconia host. Elemental PraseodymiumUnlike other rare-earth metals, which show antiferromagnetic and / or ferromagnetic ordering at low temperatures, praseodymium is paramagnetic at any temperature above 1 K. Praseodymium is found in the minerals monazite and bastnasite. Praseodymium was discovered by Carl Auer von Welsbach in 1885. The origin of the element name comes from the Greek words prasios didymos, meaning green twin.

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