Rhodium(III)-Catalyzed Synthesis of Spiropiperidine Derivatives via C-H Activation.

Title Rhodium(III)-Catalyzed Synthesis of Spiropiperidine Derivatives via C-H Activation.
Authors A. Peneau; P. Retailleau; C. Guillou; L. Chabaud
Journal J Org Chem
DOI 10.1021/acs.joc.7b03252
Abstract

Spiropiperidine derivatives, an important class of bioactive molecules, were synthesized under mild conditions by rhodium(III)-catalyzed intramolecular ArC-H activation. This reaction provides a novel route to highly substituted tricyclic spiropiperidines in good to excellent yields. Under acidic conditions the resulting enamines reacted with pendant amides to afford spiropiperidines derivatives possessing an original tetracyclic structure.

Citation A. Peneau; P. Retailleau; C. Guillou; L. Chabaud.Rhodium(III)-Catalyzed Synthesis of Spiropiperidine Derivatives via C-H Activation.. J Org Chem. 2018. doi:10.1021/acs.joc.7b03252

Related Elements

Rhodium

See more Rhodium products. Rhodium (atomic symbol: Rh, atomic number: 45) is a Block D, Group 9, Period 5 element with an atomic weight of 102.90550. Rhodium Bohr ModelThe number of electrons in each of Rhodium's shells is [2, 8, 18, 16, 1] and its electron configuration is [Kr] 4d8 5s1. The rhodium atom has a radius of 134 pm and a Van der Waals radius of 195 pm. Rhodium was discovered and first isolated by William Wollaston in 1804. In its elemental form, rhodium has a silvery white metallic appearance. Elemental RhodiumRhodium is a member of the platinum group of metals. It has a higher melting point than platinum, but a lower density. Rhodium is found in ores mixed with other metals such as palladium, silver, platinum, and gold. Rhodium is primarily used as the catalyst in the three-way catalytic converters of automobiles it is also highly valued in jewelry. The name Rhodium originates from the Greek word 'Rhodon,' which means rose.

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