Role of geraniol against lead acetate-mediated hepatic damage and their interaction with liver carboxylesterase activity in rats.

Title Role of geraniol against lead acetate-mediated hepatic damage and their interaction with liver carboxylesterase activity in rats.
Authors A. Ozkaya; Z. Sahin; M. Kuzu; Y.Selim Saglam; M. Ozkaraca; M. Uckun; E. Yologlu; V. Comakli; R. Demirdag; S. Yologlu
Journal Arch Physiol Biochem
DOI 10.1080/13813455.2017.1364772
Abstract

In this study, the effect of geraniol (50?mg/kg for 30?d), a natural antioxidant and repellent/antifeedant monoterpene, in a rat model of lead acetate-induced (500?ppm for 30?d) liver damage was evaluated. Hepatic malondialdehyde increased in the lead acetate group. Reduced glutathione unchanged, but glutathione S-transferase, glutathione reductase, as well as carboxylesterase activities decreased in geraniol, lead acetate and geraniol?+?lead acetate groups. 8-OhDG immunoreactivity, mononuclear cell infiltrations and hepatic lead concentration were lower in the geraniol?+?lead acetate group than the lead acetate group. Serum aspartate aminotransferase and alanine aminotransferase activities increased in the Pb acetate group. In conclusion, lead acetate causes oxidative and toxic damage in the liver and this effect can reduce with geraniol treatment. However, we first observed that lead acetate, as well as geraniol, can affect liver carboxylesterase activity.

Citation A. Ozkaya; Z. Sahin; M. Kuzu; Y.Selim Saglam; M. Ozkaraca; M. Uckun; E. Yologlu; V. Comakli; R. Demirdag; S. Yologlu.Role of geraniol against lead acetate-mediated hepatic damage and their interaction with liver carboxylesterase activity in rats.. Arch Physiol Biochem. 2017:18. doi:10.1080/13813455.2017.1364772

Related Elements

Lead

82 Pb 207.200000000 Lead

Lead Bohr ModelSee more Lead products. Lead (atomic symbol: Pb, atomic number: 82) is a Block P, Group 14, Period 6 element with an atomic radius of 207.2. The number of electrons in each of Lead's shells is [2, 8, 18, 32, 18, 4] and its electron configuration is [Xe] 4f14 5d10 6s2 6p2. The lead atom has a radius of 175 pm and a Van der Waals radius of 202 pm. In its elemental form, lead has a metallic gray appearance. Lead occurs naturally as a mixture of four stable isotopes: 204Pb (1.48%), 206Pb (23.6%), 207Pb (22.6%), and 208Pb (52.3%). Elemental LeadLead is obtained mainly from galena (PbS) by a roasting process. Anglesite, cerussite, and minim are other common lead containing minerals. Lead does occur as a free element in nature, but it is rare. It is a dense, soft metal that is very resistant to corrosion and poorly conductive compared to other metals. Its density and low melting point make it useful in applications such as electrolysis and industrial materials.

Related Forms & Applications

Acetates
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