Rose Bengal attached and dextran coated gadolinium oxide nanoparticles for potential diagnostic imaging applications.

Title Rose Bengal attached and dextran coated gadolinium oxide nanoparticles for potential diagnostic imaging applications.
Authors S. Kumar; V.Kumar Meena; P.Panwar Hazari; S.Kumar Sharma; R.Kumar Sharma
Journal Eur J Pharm Sci
DOI 10.1016/j.ejps.2018.03.008
Abstract

We report here, reverse micelle mediated synthesis of multifunctional dextran (dex) coated GdO nanoparticles (NPs) carrying rose bengal (RB) dye for magnetic resonance and optical imaging. The diameter of these RB attached dex coated GdO NPs (Gd-dex-RB NPs) was found to be ~17?nm as measured by TEM. NMR line broadening effect on the surrounding water protons affirmed the paramagnetic nature of these NPs. Optical properties of Gd-dex-RB NPs were validated by UV-Vis and fluorescence spectroscopy. Time dependent release profile of RB from NPs at two different pH of 7.4 and 5.0 revealed that these NPs behave as slow releasing system. In-vitro study revealed that NPs are efficiently taken up by cells and show optical activity in cellular environment. In vitro cell viability (SRB) assay was performed on cancerous (A-549, U-87) and normal (HEK-293) cell lines, showed the absence of cytotoxic effect of Gd-dex-RB NPs. Therefore, such multifunctional NPs can be efficiently used for bio-imaging and optical tracking.

Citation S. Kumar; V.Kumar Meena; P.Panwar Hazari; S.Kumar Sharma; R.Kumar Sharma.Rose Bengal attached and dextran coated gadolinium oxide nanoparticles for potential diagnostic imaging applications.. Eur J Pharm Sci. 2018;117:362370. doi:10.1016/j.ejps.2018.03.008

Related Elements

Gadolinium

64 Gd 157.250000000 Gadolinium

See more Gadolinium products. Gadolinium (atomic symbol: Gd, atomic number: 64) is a Block F, Group 3, Period 6 element with an atomic radius of 157.25. Gadolinium Bohr ModelThe number of electrons in each of Gadolinium's shells is [2, 8, 18, 25, 9, 2] and its electron configuration is [Xe] 4f7 5d1 6s2. The gadolinium atom has a radius of 180 pm and a Van der Waals radius of 237 pm. Gadolinium was discovered by Jean Charles Galissard de Marignac in 1880 and first isolated by Lecoq de Boisbaudran in 1886. In its elemental form, gadolinium has a silvery-white appearance. Gadolinium is a rare earth or lanthanide element that possesses unique properties advantageous to specialized applications such as semiconductor fabrication and nuclear reactor shielding. Elemental Gadolinium PictureIt is utilized for both its high magnetic moment (7.94μ B) and in phosphors and scintillator crystals. When complexed with EDTA ligands, it is used as an injectable contrast agent for MRIs. The element is named after the Finnish chemist and geologist Johan Gadolin.

Related Forms & Applications

Nanomaterials Oxides
Publish your research on the American Elements website