Ruthenium-catalyzed meta/ortho-selective C-H alkylation of azoarenes using alkyl bromides.

Title Ruthenium-catalyzed meta/ortho-selective C-H alkylation of azoarenes using alkyl bromides.
Authors G. Li; X. Ma; C. Jia; Q. Han; Y. Wang; J. Wang; L. Yu; S. Yang
Journal Chem Commun (Camb)
DOI 10.1039/c6cc09323j
Abstract

meta/ortho-Selective CAr-H (di)alkylation reactions of azoarenes have been achieved via [Ru(p-cymene)Cl2]2 catalyzed ortho-metalation using various types of alkyl bromides. Particularly, dual meta-alkylation of azoarene and reduction offer an attractive strategy for the synthesis of meta-alkylanilines, which are difficult to access via traditional aniline functionalization methods.

Citation G. Li; X. Ma; C. Jia; Q. Han; Y. Wang; J. Wang; L. Yu; S. Yang.Ruthenium-catalyzed meta/ortho-selective C-H alkylation of azoarenes using alkyl bromides.. Chem Commun (Camb). 2017;53(7):12611264. doi:10.1039/c6cc09323j

Related Elements

Ruthenium

See more Ruthenium products. Ruthenium (atomic symbol: Ru, atomic number: 44) is a Block D, Group 8, Period 5 element with an atomic weight of 101.07. Ruthenium Bohr ModelThe number of electrons in each of ruthenium's shells is [2, 8, 18, 15, 1] and its electron configuration is [Kr] 4d7 5s1. The ruthenium atom has a radius of 134 pm and a Van der Waals radius of 207 pm. Ruthenium was discovered by Jędrzej Śniadecki in 1807. It was first recognized as a distinct element by Karl Ernst Claus in 1844. Elemental RutheniumIn its elemental form, ruthenium has a silvery white metallic appearance. Ruthenium is a rare transition metal belonging to the platinum group of metals. It is found in pentlandite, pyroxenite, and platinum group metal ores. The name Ruthenium originates from the Latin word "Ruthenia," meaning Russia.

Bromine

See more Bromine products. Bromine (atomic symbol: Br, atomic number: 35) is a Block P, Group 17, Period 4 element. Its electron configuration is [Ar]4s23d104p5. The bromine atom has a radius of 102 pm and its Van der Waals radius is 183 pm. In its elemental form, bromine Bromine Bohr Model has a red-brown appearance. Bromine does not occur by itself in nature; it is found as colorless soluble crystalline mineral halide salts. Bromine was discovered and first isolated by Antoine Jérôme Balard and Leopold Gmelin in 1825-1826.

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