Sodium selenite induces apoptosis and inhibits autophagy in human synovial sarcoma cell line SW982 in vitro.

Title Sodium selenite induces apoptosis and inhibits autophagy in human synovial sarcoma cell line SW982 in vitro.
Authors L. Yang; Y.S. Cai; K. Xu; J.L. Zhu; Y.B. Li; X.Q. Wu; J. Sun; S.M. Lu; P. Xu
Journal Mol Med Rep
DOI 10.3892/mmr.2018.8679
Abstract

The present study aimed to examine the effects of sodium selenite on the SW982 human synovial sarcoma cell line in relation to cell viability, apoptosis and autophagy. The results indicated that sodium selenite reduced cell viability and induced apoptosis by activating caspase?3 and members of the poly (ADP?ribose) polymerase and Bcl?2 protein families in SW982 cells. Furthermore, autophagy was also suppressed by sodium selenite treatment in SW982 cells, and apoptosis was upregulated in cells co?treated with sodium selenite and the autophagy inhibitor 3?methyladenine. By contrast, apoptosis was downregulated when sodium selenite was combined with rapamycin, an inducer of autophagy. The results indicated that autophagy may protect cells from the cytotoxicity of sodium selenite. The present study results demonstrated that sodium selenite induced apoptosis and inhibited autophagy and autophagy?protected cells from death by antagonizing sodium selenite?induced apoptosis in SW982 cells in vitro.

Citation L. Yang; Y.S. Cai; K. Xu; J.L. Zhu; Y.B. Li; X.Q. Wu; J. Sun; S.M. Lu; P. Xu.Sodium selenite induces apoptosis and inhibits autophagy in human synovial sarcoma cell line SW982 in vitro.. Mol Med Rep. 2018. doi:10.3892/mmr.2018.8679

Related Elements

Selenium

Selenium Bohr ModelSee more Selenium products. Selenium (atomic symbol: Se, atomic number: 34) is a Block P, Group 16, Period 4 element with an atomic radius of 78.96. The number of electrons in each of Selenium's shells is 2, 8, 18, 6 and its electron configuration is [Ar] 3d10 4s2 4p4. The selenium atom has a radius of 120 pm and a Van der Waals radius of 190 pm. Selenium is a non-metal with several allotropes: a black, vitreous form with an irregular crystal structure three red-colored forms with monoclinic crystal structures and a gray form with a hexagonal crystal structure, the most stable and dense form of the element. Elemental SeleniumOne of the most common uses for selenium is in glass production the red tint that it lends to glass neutralizes green or yellow tints from impurities in the glass materials. Selenium was discovered and first isolated by Jöns Jakob Berzelius and Johann Gottlieb Gahn in 1817. The origin of the name Selenium comes from the Greek word "Selênê," meaning moon.

Sodium

Sodium Bohr ModelSee more Sodium products. Sodium (atomic symbol: Na, atomic number: 11) is a Block D, Group 5, Period 4 element with an atomic weight of 22.989769. The number of electrons in each of Sodium's shells is [2, 8, 1] and its electron configuration is [Ne] 3s1. The sodium atom has a radius of 185.8 pm and a Van der Waals radius of 227 pm. Sodium was discovered and first isolated by Sir Humphrey Davy in 1807. In its elemental form, sodium has a silvery-white metallic appearance. It is the sixth most abundant element, making up 2.6 % of the earth's crust. Sodium does not occur in nature as a free element and must be extracted from its compounds (e.g., feldspars, sodalite, and rock salt). The name Sodium is thought to come from the Arabic word suda, meaning "headache" (due to sodium carbonate's headache-alleviating properties), and its elemental symbol Na comes from natrium, its Latin name.

Related Forms & Applications