Strontium-doped calcium silicate bioceramic with enhanced in vitro osteogenic properties.

Title Strontium-doped calcium silicate bioceramic with enhanced in vitro osteogenic properties.
Authors Y.Jung No; S. Roohaniesfahani; Z.F. Lu; J. Shi; H. Zreiqat
Journal Biomed Mater
DOI 10.1088/1748-605X/aa6987
Abstract

Gehlenite (GLN, Ca2SiAl2O7) is a bioceramic that has been recently shown to possess excellent mechanical strength and in vitro osteogenic properties for bone regeneration. Substitutional incorporation of strontium in place of calcium is an effective way to further enhance biological properties of calcium-based bioceramics and glasses. However, such strategy has the potential to affect other important physicochemical parameters such as strength and degradation due to differences in the ionic radius of strontium and calcium. This study is the first to investigate the effect of a range of concentrations of strontium substitution of calcium at 1, 2, 5, 10 mol% (S1-GLN, S2-GLN, S5-GLN and S10-GLN) on the physicochemical and biological properties of GLN. We showed that up to 2 mol% strontium ion substitution retains the monophasic GLN structure when sintered at 1450 °C, whereas higher concentrations resulted in presence of calcium silicate impurities. Increased strontium incorporation resulted in changes in grain morphology and reduced densification when the ceramics were sintered at 1450 °C. Porous GLN, S1-GLN and S2-GLN scaffolds (?80% porosity) showed compressive strengths of 2.05 ± 0.46 MPa, 1.76 ± 0.79 MPa and 1.57 ± 0.52 MPa respectively. S1-GLN and S2-GLN immersed in simulated body fluid showed increased strontium ion release but reduced calcium and silicon ion release compared to GLN without affecting overall weight loss and pH over a 21 d period. The bioactivity of the S2-GLN ceramics was significantly improved as reflected in the significant upregulation of HOB proliferation and differentiation compared to GLN. Overall, these results suggest that increased incorporation of strontium presents a trade-off between bioactivity and mechanical strength for GLN bioceramics. This is an important consideration in the development of strontium-doped bioceramics.

Citation Y.Jung No; S. Roohaniesfahani; Z.F. Lu; J. Shi; H. Zreiqat.Strontium-doped calcium silicate bioceramic with enhanced in vitro osteogenic properties.. Biomed Mater. 2017;12(3):035003. doi:10.1088/1748-605X/aa6987

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See more Calcium products. Calcium (atomic symbol: Ca, atomic number: 20) is a Block S, Group 2, Period 4 element with an atomic weight of 40.078. The number of electrons in each of Calcium's shells is [2, 8, 8, 2] and its electron configuration is [Ar]4s2. Calcium Bohr ModelThe calcium atom has a radius of 197 pm and a Van der Waals radius of 231 pm. Calcium was discovered and first isolated by Sir Humphrey Davy in 1808. It is the fifth most abundant element in the earth's crust and can be found in minerals such as dolomite, gypsum, plagioclases, amphiboles, pyroxenes and garnets. In its elemental form, calcium has a dull gray-silver appearance. Calcium is a reactive, soft metal that is a member of the alkaline earth elements. Elemental CalciumIt frequently serves as an alloying agent for other metals like aluminum and beryllium, and industrial materials like cement and mortar are composed of calcium compounds like calcium carbonate. It is also an biologically essential substance found in teeth, bones, and shells. The name "calcium" originates from the Latin word "calics," meaning lime.

Strontium

See more Strontium products. Strontium (atomic symbol: Sr, atomic number: 38) is a Block S, Group 2, Period 5 element with an atomic weight of 87.62 . Strontium Bohr ModelThe number of electrons in each of Strontium's shells is [2, 8, 18, 8, 2] and its electron configuration is [Kr] 5s2. The strontium atom has a radius of 215 pm and a Van der Waals radius of 249 pm. Strontium was discovered by William Cruickshank in 1787 and first isolated by Humphry Davy in 1808. In its elemental form, strontium is a soft, silvery white metallic solid that quickly turns yellow when exposed to air. Elemental StrontiumCathode ray tubes in televisions are made of strontium, which are becoming increasingly displaced by other display technologies pyrotechnics and fireworks employ strontium salts to achieve a bright red color. Radioactive isotopes of strontium have been used in radioisotope thermoelectric generators (RTGs) and for certain cancer treatments. In nature, most strontium is found in celestite (as strontium sulfate) and strontianite (as strontium carbonate). Strontium was named after the Scottish town where it was discovered.

Silicon

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