The label-free immunosensor based on rhodium@palladium nanodendrites/sulfo group functionalized multi-walled carbon nanotubes for the sensitive analysis of carcino embryonic antigen.

Title The label-free immunosensor based on rhodium@palladium nanodendrites/sulfo group functionalized multi-walled carbon nanotubes for the sensitive analysis of carcino embryonic antigen.
Authors H. Lv; Y. Li; X. Zhang; Z. Gao; J. Feng; P. Wang; Y. Dong
Journal Anal Chim Acta
DOI 10.1016/j.aca.2017.12.030
Abstract

In this work, bimetallic core-shell rhodium@palladium nanodendrites (Rh@Pd NDs) loaded on sulfo group functionalized multi-walled carbon nanotubes (MWCNTs-SOH) were combined to form Rh@Pd NDs/MWCNTs-SOH nanocomposites. And the composites were used to construct a simple and label-free electrochemical immunosensor for carcino embryonic antigen (CEA) detection using differential pulse voltammetry (DPV). Rh@Pd NDs with dendritic nanostructure not only provide abundant catalytically active sites, but also increase the loading of antibody, which could improve the analytical performance and result in high sensitivity. In addition, the MWCNTs-SOH could further enhance electrochemical properties due to the excellent conductivity, good solubility and high surface area. Taking advantages of both Rh@Pd NDs and MWCNTs-SOH, the proposed immunosensor showed a broad linear range from 25?fg?mL to 100?ng?mL for CEA detection and a low detection limit of 8.3?fg?mL (signal-to-noise ratio of 3) under optimal experimental conditions. Moreover, the expected immunosensor exhibited good reproducibility and high sensitivity, which could achieve excellent analysis of CEA in human serum with satisfactory results. Therefore, the Rh@Pd NDs/MWCNTs-SOH nanocomposites may be considered as a sensing platform for fabrication of simple, ultrasensitive and label-free electrochemical immunosensor.

Citation H. Lv; Y. Li; X. Zhang; Z. Gao; J. Feng; P. Wang; Y. Dong.The label-free immunosensor based on rhodium@palladium nanodendrites/sulfo group functionalized multi-walled carbon nanotubes for the sensitive analysis of carcino embryonic antigen.. Anal Chim Acta. 2018;1007:6170. doi:10.1016/j.aca.2017.12.030

Related Elements

Rhodium

See more Rhodium products. Rhodium (atomic symbol: Rh, atomic number: 45) is a Block D, Group 9, Period 5 element with an atomic weight of 102.90550. Rhodium Bohr ModelThe number of electrons in each of Rhodium's shells is [2, 8, 18, 16, 1] and its electron configuration is [Kr] 4d8 5s1. The rhodium atom has a radius of 134 pm and a Van der Waals radius of 195 pm. Rhodium was discovered and first isolated by William Wollaston in 1804. In its elemental form, rhodium has a silvery white metallic appearance. Elemental RhodiumRhodium is a member of the platinum group of metals. It has a higher melting point than platinum, but a lower density. Rhodium is found in ores mixed with other metals such as palladium, silver, platinum, and gold. Rhodium is primarily used as the catalyst in the three-way catalytic converters of automobiles it is also highly valued in jewelry. The name Rhodium originates from the Greek word 'Rhodon,' which means rose.

Palladium

Palladium Bohr ModelSee more Palladium products. Palladium (atomic symbol: Pd, atomic number: 46) is a Block D, Group 10, Period 5 element with an atomic weight of 106.42. The number of electrons in each of palladium's shells is 2, 8, 18, 18 and its electron configuration is [Kr] 4d10. The palladium atom has a radius of 137 pm and a Van der Waals radius of 202 pm. In its elemental form, palladium has a silvery white appearance. Palladium is a member of the platinum group of metals (along with platinum, rhodium, ruthenium, iridium and osmium). Elemental PalladiumPalladium has the lowest melting point and is the least dense of the group. Palladium can be found as a free metal and alloyed with other platinum-group metals. Nickel-copper deposits are the main commercial source of palladium. Palladium was discovered and first isolated by William Hyde Wollaston in 1803. Its name is derived from the asteroid Pallas.

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