Very low concentration of cerium dioxide nanoparticles induce DNA damage, but no loss of vitality, in human spermatozoa.

Title Very low concentration of cerium dioxide nanoparticles induce DNA damage, but no loss of vitality, in human spermatozoa.
Authors L. Préaubert; V. Tassistro; M. Auffan; I. Sari-Minodier; J. Rose; B. Courbiere; J. Perrin
Journal Toxicol In Vitro
DOI 10.1016/j.tiv.2018.03.013
Abstract

Cerium dioxide nanoparticles (CeONP) are widely used for industrial purposes, as in diesel, paint, wood stain and as potential therapeutic applications. The Organization for Economic Cooperation and Development included CeONP in the priority list of nanomaterials requiring urgent evaluation. As metal nanoparticles can cross the blood-testis barrier, CeONP could interact with spermatozoa. The genotoxicity of CeONP was demonstrated in vitro on human cell lines and mouse gametes. However, the effects of CeONP on human spermatozoa DNA remain unknown. We showed significant DNA damage induced in vitro by CeONP on human spermatozoa using Comet assay. The genotoxicity was inversely proportional to the concentration (0.01 to 10?mg·L). TEM showed no internalization of CeONP into the spermatozoa. This study shows for the first time that in vitro exposure to very low concentrations of cerium dioxide nanoparticles can induce significant DNA damage in human spermatozoa. These results add new and important insights regarding the reproductive toxicity of priority nanomaterials, which require urgent evaluation.

Citation L. Préaubert; V. Tassistro; M. Auffan; I. Sari-Minodier; J. Rose; B. Courbiere; J. Perrin.Very low concentration of cerium dioxide nanoparticles induce DNA damage, but no loss of vitality, in human spermatozoa.. Toxicol In Vitro. 2018;50:236241. doi:10.1016/j.tiv.2018.03.013

Related Elements

Cerium

See more Cerium products. Cerium (atomic symbol: Ce, atomic number: 58) is a Block F, Group 3, Period 6 element with an atomic weight of 140.116. The number of electrons in each of cerium's shells is 2, 8, 18, 19, 9, 2 and its electron configuration is [Xe]4f2 6s2. Cerium Bohr ModelThe cerium atom has a radius of 182.5 pm and a Van der Waals radius of 235 pm. In its elemental form, cerium has a silvery white appearance. Cerium is the most abundant of the rare earth metals. It is characterized chemically by having two valence states, the +3 cerous and +4 ceric states. The ceric state is the only non-trivalent rare earth ion stable in aqueous solutions. Elemental CeriumIt is therefore strongly acidic and oxidizing, in addition to being moderately toxic.The cerous state closely resembles the other trivalent rare earths. Cerium is found in the minerals allanite, bastnasite, hydroxylbastnasite, monazite, rhabdophane, synchysite and zircon. Cerium was discovered by Martin Heinrich Klaproth, Jöns Jakob Berzelius, and Wilhelm Hisinger in 1803 and first isolated by Carl Gustaf Mosander in 1839. The element was named after the asteroid Ceres, which itself was named after the Roman god of agriculture.

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