Visible-light-driven dynamic cancer therapy and imaging using graphitic carbon nitride nanoparticles.

Title Visible-light-driven dynamic cancer therapy and imaging using graphitic carbon nitride nanoparticles.
Authors N.Su Heo; S.Uk Lee; M. Rethinasabapathy; E.Zoo Lee; H.J. Cho; S.Yeong Oh; S.Rak Choe; Y. Kim; W.G. Hong; G. Krishnan; W.Hi Hong; T.J. Jeon; Y.S. Jun; H.Jin Kim; Y.Suk Huh
Journal Mater Sci Eng C Mater Biol Appl
DOI 10.1016/j.msec.2018.04.035
Abstract

Organic graphitic carbon nitride nanoparticles (NP-g-CN), less than 30?nm in size, were synthesized and evaluated for photodynamic therapy (PDT) and cell imaging applications. NP-g-CN particles were prepared through an intercalation process using a rod-like melamine-cyanuric acid adduct (MCA) as the molecular precursor and a eutectic mixture of LiCl-KCl (45:55?wt%) as the reaction medium for polycondensation. The nano-dimensional NP-g-CN penetrated the malignant tumor cells with minimal hindrance and effectively generated reactive oxygen species (ROS) under visible light irradiation, which could ablate cancer cells. When excited by visible light irradiation (??>?420?nm), NP-g-CN introduced to HeLa and cos-7 cells generated a significant amount of ROS and killed the cancerous cells selectively. The cytotoxicity of NP-g-CN was manipulated by altering the light irradiation and the BP-g-CN caused more damage to the cancer cells than normal cells at low concentrations. As a potential non-toxic organic nanomaterial, the synthesized NP-g-CN are biocompatible with less cytotoxicity than toxic inorganic materials. The combined effects of the high efficacy of ROS generation under visible light irradiation, low toxicity, and bio-compatibility highlight the potential of NP-g-CN for PDT and imaging without further modification.

Citation N.Su Heo; S.Uk Lee; M. Rethinasabapathy; E.Zoo Lee; H.J. Cho; S.Yeong Oh; S.Rak Choe; Y. Kim; W.G. Hong; G. Krishnan; W.Hi Hong; T.J. Jeon; Y.S. Jun; H.Jin Kim; Y.Suk Huh.Visible-light-driven dynamic cancer therapy and imaging using graphitic carbon nitride nanoparticles.. Mater Sci Eng C Mater Biol Appl. 2018;90:531538. doi:10.1016/j.msec.2018.04.035

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Nitrogen

See more Nitrogen products. Nitrogen is a Block P, Group 15, Period 2 element. Its electron configuration is [He]2s22p3. Nitrogen is an odorless, tasteless, colorless and mostly inert gas. It is the seventh most abundant element in the universe and it constitutes 78.09% (by volume) of Earth's atmosphere. Nitrogen was discovered by Daniel Rutherford in 1772.

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